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Themed collection Coronavirus articles - free to access collection

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Editorial

Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research

That put outbound investment for October at $8.3bn, according to FT calculations based on official data, for a year-on-year fall of 26.5 per cent.
Summly and Yahoo refused to comment on the deal’s terms.

Graphical abstract: Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
From the themed collection: 浙江临安启动民宿环境整治行动
Editorial

Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?

他说,他和他的女朋友经常通过书信往来,当时他还在上学。他们最后确实结婚了,而且有了4个孩子。
7月,中国政府首次尝试规范互联网金融,央行、银监会、证监会等10家机构联合发布指导意见,提出了“互联网金融”的官方定义,并明确了各机构负责监管的互联网金融机构类型。

Graphical abstract: Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
Open Access Accepted Manuscript - Highlight

Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities

Open Access Perspective

Soft matter science and the COVID-19 pandemic

n. 码,密码,法规,准则

Graphical abstract: Soft matter science and the COVID-19 pandemic
From the themed collection: 未来浴室设计六大趋势
Open Access Perspective

Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective

站在舞台中央,莱昂纳多发言说:“这是无上的荣誉,对我意义重大。两年前当我们置身于荒野当中拍摄电影,我们深深地被大自然的美丽和庞杂所感染。

Graphical abstract: Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Perspective

Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic

目前还不清楚绑架者的身份以及他们的目的。
But the economic base for these capabilities is steadily declining.
spontaneous
That's a fraction of their earning power -- Hillary and Bill Clinton banked $10.6 million mostly from speaking fees and royalties in 2015, while Trump said he made almost $560 million.

Graphical abstract: Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Perspective

Trends and targets in antiviral phototherapy

小贝现身纽约时装周 为凯特选嫁衣?
美联储去年花了六个多月的时间暗示其有意退出第三轮购债计划,这种可能性时常扰动着市场。目前美联储仅处于退出购债计划的第一阶段。
Consoles: Xbox One
今年由美国电影学会的电影评审总监是Tom Pollock,担任电视剧评审总监的是Richard Frank。评审团的其他成员还包括Judd Apatow, Halle Berry, Jamie Lee Curtis, Leonard Maltin,来自知名大学的著作家,学者,公认的电影艺术家,还有像媒体NPR,Rolling Stone, TV Guide, 华盛顿邮报对于电视电影的评论家们。

Graphical abstract: Trends and targets in antiviral phototherapy
Minireview

A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays

We first see the hair of Anna Morales (Jessica Chastain) during the opening credits of “A Most Violent Year.” She’s at her makeup mirror.

Graphical abstract: A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Minireview

Novel biosensing methodologies for ultrasensitive detection of viruses

wheat

Graphical abstract: Novel biosensing methodologies for ultrasensitive detection of viruses
Application

Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug

congratulate
“The auction market is extremely selective,” said Henry Pettifer, the head of old master paintings at Christie’s, whose sale total had been dented by a 15th-century Flemish Madonna and child by Hans Memling that the auction house had sold privately for more than 3.5 million and had withdrawn from the sale. “The availability of fresh material is limited,” he added, alluding to how few museum-quality works are in private hands.

Graphical abstract: Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
Open Access Review Article

ACE2 as a potential therapeutic target for pandemic COVID-19

It was there in Rossella Jardini’s Moschino, from the bows and bouffants of spring-summer 2009 to the Mary Quant-inspired spring 2013 collection.
荷兰合作银行(Rabobank)大宗农产品市场主管斯特凡.沃热尔(Stefan Vogel)表示,中国是推动农产品市场的最引人注目的变数。

Graphical abstract: ACE2 as a potential therapeutic target for pandemic COVID-19
Open Access Review Article

Diagnostic technologies for COVID-19: a review

8. Smile every time EXCEPT when my team is losing.
The Cnzz.com report also discusses the problem of the 'free-to-play' business model that's prevalent in China's online game sector. While many games companies in the U.S., for example, charge subscription fees, most Chinese games utilize the free-to-play model, which allows players to try out a game without paying. The longer players stay in the game, the more likely they will be to pay for in-game items to move up into higher levels of play. But that also means that people who spend the most money are the best performers.

Graphical abstract: Diagnostic technologies for COVID-19: a review
Open Access Review Article

Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review

2017年,人们指责大型科技公司太过强大、利用自身的规模主宰市场,而且不够关注他们所创造的工具如何被用来做恶。
No.1: Einstein Alive Again?
我对事物持悲观态度
Adriana Lima, 36, came in fourth place with earnings of $10.5 million, with new mother Rosie Huntington-Whiteley ($9.5 million) and Karlie Kloss, 25, ($9 million) rounding things off in sixth and seventh places, respectively.

Graphical abstract: Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
From the themed collection: 郑州首套房贷款利率上浮10%成主流
Open Access Review Article

An overview of key potential therapeutic strategies for combat in the COVID-19 battle

An odd assortment of S&P sectors led the market higher this year, with some strange bedfellows atop the leaderboard. Even if a manager had foreseen that the healthcare sector would gain 27% this year, would they have guessed that utilities would be in the No. 2 slot, with gains of 23%? Unlikely.

Graphical abstract: An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Open Access Review Article

Potential repurposed SARS-CoV-2 (COVID-19) infection drugs

超过35万的欧洲玩家(还有一些北美和亚洲玩家)带着朝圣般的心情,赶赴人口刚过100万的德国科隆市,参加一年一度的游戏盛会。美国动视(Activision)在展览中首次公布了Sledgehammer Games工作室的多人游戏《使命召唤:高级战争》(Call of Duty: Advanced Warfare),现场玩家亲身体验了这款将于11月3日正式发布的游戏。
The attitude of the founder will set the tone for the business. Negativity, laziness and entitlement waste time and money while they tarnish your reputation. Success largely depends on making mistakes and accepting blame in stride. Owning up to and facing challenges head-on is what makes a mere business owner a leader.

Graphical abstract: Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
Open Access Review Article

Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale

adj. 自信的,有信心的,有把握的

Graphical abstract: Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Review Article

In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections

After decades of promise, new gene therapies are starting to deliver real results. Like all new therapies, communicating accurately how and where it works will prove as challenging as the treatment itself.

Graphical abstract: In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
Review Article

Antiviral drug discovery: broad-spectrum drugs from nature

Many believe the population is no longer a major threat to China's resources and environment. Instead, China's population challenges have shifted to low birth rates, an aging society and a widening gender imbalance. China has already experienced a shortage of skilled workers in places like the Pearl River Delta, so it might not be long before we see major reforms.
201001/93691.shtml重点单词
Online peer-to-peer lending platforms have expanded rapidly in China, along with fraud cases.
Mr Koepke argues, however, that the role of US interest rates in provoking EM crises has not been fully understood. He presents evidence that the probability of EM crises is substantially higher during a conjunction of three conditions: during a Fed tightening cycle, when the federal funds rate is above its natural rate (the rate that leads actual output to converge to potential output), and when market participants are surprised by signals that the Fed will tighten policy faster than previously expected.

Graphical abstract: Antiviral drug discovery: broad-spectrum drugs from nature
Review Article

Influenza neuraminidase: A druggable target for natural products

[k?n'denst]
n. 潜力,潜能由美国演员Jared Leto领衔的“火星三十秒”拿到了最佳另类音乐奖,同时还有Lana Del Rey,Lorde,The XX和Imanine Dragons等人提名。
Though the Dutch financial markets then had none of today’s technology, they employed many of the same practices that traders use today. Investors bought securities, sometimes borrowing money with loans secured by the shares they were buying. In today's language, they bought shares on margin. Lenders protected themselves by demanding a “haircut” – collateral in cash or securities that exceeded the loan amount by a specified percentage. If the value of the securities dropped below that specified percentage, the lender would demand that the investor put up additional money to stay in line with the haircut. If the investor couldn’t come up with the added margin, the lender was entitled to liquidate the securities and recoup the loan amount.
报告指出,缺少资金和经验是大学生创业者们面临的最大障碍,40%的年轻创业者们依赖于诸如来自银行、投资机构、学校和政府等机构贷款的外部资金。

Graphical abstract: Influenza neuraminidase: A druggable target for natural products
Critical Review

Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle

The Wizards need to surge ASAP if they want to stay in this. We saw what happened last year when they waited too long to get it together.
"Although it may seem counterintuitive, the best way to maximize profits over the long-term is not to make them the primary goal of the business," Mackey said in an interview earlier this year.

Graphical abstract: Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
Critical Review

The role of biosensors in the detection of emerging infectious diseases

The Belty is great that it uses technology to track fitness, water intake, and posture, but for $395, you might be better off getting the same in a stylish smart watch or activity tracker.

Graphical abstract: The role of biosensors in the detection of emerging infectious diseases
Communication

Quantitative determination of mechanical stability in the novel coronavirus spike protein

此外,在最新出炉的50位亿万女富豪中,有32位是白手起家。

Graphical abstract: Quantitative determination of mechanical stability in the novel coronavirus spike protein
Communication

Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations

5. The 2012 Ig Nobel Chemistry Prize
医疗、医保、医药联动改革
"They are fairies. Can’t they do something else except falling in love?" another Douban user Amy said.
2011年在达洛伊西奥15岁时,他就曾获得来自李嘉诚的种子投资。一年之后Summy发布,并在短短一个月内吸引了500,000名用户,在28个国家登上了新款应用软件热度榜的首位。对于一个连高中都还没毕业的人来说,雅虎的收购可谓意义深远。不过,达洛伊西奥的过人之处可不只是技术知识丰富这一点。在他连胡子都不用刮的时候,他就强烈向往、渴望著有朝一日能在科技领域做出一番大的成就。不仅要创新,还要有所成就,当然,还要大把赚钱。

Graphical abstract: Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Communication

MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling

de去掉,but。去掉but?导演Z(平静):你可以上台了。女演员F:but我还没准备好呢?Z(有点儿烦):哪那么多事儿呀,快点儿!F:but我这可是第一次!Z(强忍):谁没有第一次呀,快!F:but…,Z(已经怒了):哪XX那么多but呀,全都给我de掉,再不上去我就X人了!!!
9. Build your “A team”.
manifesto
On Tuesday Saarland became the first German region to ban campaigning by foreign politicians. Several German local councils had called off planned Turkish ministers’ campaign meetings on technical grounds, such as fire safety.

Graphical abstract: MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Communication

Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

Her piece, titled “Back to Mother Nature," depicts an elaborate water-cleaning machine. Zhang worked with a team of artists at Google to animate her drawing.
The Office for National Youth Campus Football said that China already had 13,381 "special football schools" as of 2016, and 69 counties are piloting programs for football in schools, the Xinhua News Agency reported.

Graphical abstract: Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
Communication

Inhibition of SARS coronavirus helicase by bismuth complexes

At the forum, tech entrepreneurs also shared their views on virtual reality, which they said will be the most important computing platform over the next five to 10 years.
There will no longer be any legal obstacle to the implementation of a universal two-child policy, if the draft amendment to the family planning law is approved by the top legislature by Sunday.
This includes ‘qwerty,’ in fourth place, ‘admin,’ in 11th, and ‘login’, in 14th.
['striktli]
If a sitcom that lasts for 10 years is considered popular, then surely one that still stirs up emotions after 20 must be considered a classic. Friends first aired in the US in 1994, featuring a cast of six young men and women in New York. In the time since, it’s become one of the most famous titles in the sitcom genre, aired in over 100 countries and regions in the world.

Graphical abstract: Inhibition of SARS coronavirus helicase by bismuth complexes
Open Access Edge Article

Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning

多年来,西方排放量的缓慢减少,被东方排放量的日益增加所抵消。2013年,这种趋势仍在继续。中国的排放量增加了4.2%,印度增加了5.1%。中印两国一直在以极快的速度修建火力发电厂。
control
当前油价正在发生什么变化?在业内人士和严肃的投资者中间,对这个问题有两种不同的看法。2016年油价走势或许有助我们看清哪种观点是正确的。

Graphical abstract: Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Open Access Edge Article

A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers

另一名来自美国的毕业生写道,来自世界各地的知识的丰富性和深度为课程带来了巨大的价值,他补充称,“鉴于这里汇聚着众多的文化和经验,有关贿赂的课堂道德讨论不像典型的美国学校那样枯燥。”
It was also the first time Shanghai witnessed a decrease in its permanent population since China adopted the policy of reform and opening-up in 1978, Guo Feng, a research fellow at Shanghai Finance Institute, was quoted by news site wallstreetcn.com as saying on Tuesday.

Graphical abstract: A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Open Access Edge Article

Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods

The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.

Graphical abstract: Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
Open Access Edge Article

Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors

By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.

Graphical abstract: Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
Open Access Edge Article

Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir

In October, South Africa brought down its holdings of US government securities to USD 10.3 billion.
['breik.θru:]
“有个人在会议中途冲了出去,一句话也没留。”

Graphical abstract: Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
Open Access Edge Article

Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Even though we are apart, you are in my heart this season.千山万水,隔不断我在佳节对你的思念。
SplashData公司首席执行官摩根-斯莱恩说:“不幸的是,虽然最新的一部星球大战系列电影很精彩,但使用‘starwars’这个密码却很危险。”
根据考试结束后网上发布的考题和部分考生的反馈,今年的考题难度适中,长征火箭、我国外交事务、"玉兔"月球车和大学生创业等政治和社会热点问题都有出现。

Graphical abstract: Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Accepted Manuscript - Paper

A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring

Open Access Paper

Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)

There’s a (not so) quiet revolution going on under the hoods of today’s cars, trucks and crossovers if the latest list of best engines compiled by the experts at WardsAuto is any indication. Turbocharged, supercharged and diesel engines – and even one electric motor – dominate the 20th annual 10 Best Engines awards, which, according to Wards, “recognize outstanding powertrain achievement, world-class technologies and those rare engines or electric propulsion systems that are so compelling they help sell the vehicle.”

Graphical abstract: Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Paper

A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood

单词protection 联想记忆:

Graphical abstract: A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Open Access Paper

Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations

10)你是对的:倘若你想引起别人的注意,径自告诉他,他是对的。一旦你交出交谈中的优势地位,对方就更容易接受这一事实:正确的规划或情绪并不总能够战胜我们每天都要面对的荒谬事儿或者种种限制。
除了《地心引力》和《美国骗局》,我还选出了其他一些口碑不错的影片(按字母顺序排列):

Graphical abstract: Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
From the themed collection: 租房业态或转向大机构角力阶段
Open Access Paper

The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives

男性使用这个密码的几率是女性的2.8倍。
国家大学排行榜单数量从去年的38份上升到42份。新加入的榜单包括阿根廷、墨西哥、巴基斯坦和罗马尼亚大学排行榜。
No students or teachers drank the poisoned water, the report said.
Investors in emerging markets need no reminder of the importance for EM assets of the US Federal Reserve — or do they?

Graphical abstract: The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
Open Access Paper

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease

"Our data show that the user gave her age as 28, not 13, as reported in the media," the employee said.
迷你剧集/电影类最佳女演员:萨拉?保罗森(Sarah Paulson),《美国罪案故事:公诉辛普森》(The People v. O. J. Simpson: American Crime Story)

Graphical abstract: Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Open Access Paper

Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro

The Post
周二,她在给客户的一封信里提出了下面几个观点,令我耳目一新:

Graphical abstract: Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Open Access Paper

Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein

他原以为只要有人点击这个广告,就会给他捐献一点钱。但是实际上,每当有人点击这个链接的时候,他都需要付费。

Graphical abstract: Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Paper

Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide

拉杜卡(Rocco LaDuca)是纽约州尤蒂卡市(Utica)《观察家快报》(Observer-Dispatch)报道犯罪和法院新闻的记者。他说,之所以选择做记者,一定程度上是源于他和祖母读报的美好记忆。
The city of 21 million people recorded 1.86 trillion yuan in total consumption in 2015, marking a yearly rise of 8.7 percent. Consumption contributed over 70 percent to the city's GDP growth.
Tesla:In an effort to blunt criticism about slow refueling times for battery-powered cars, Tesla TSLA -1.54% starts to roll out of a network of battery-swap stations. CEO Elon Musk must hope he can outdo Shai Agassi’s Better Place, which tried to build a whole company around battery-swaps before going bankrupt in 2013.
Yes. Mr Modi’s overnight ban on using high-value bank notes was a big shock, and seriously disrupted the economy. But it delivered rich political rewards, bolstering the premier’s image as a decisive leader willing to take tough action against corruption. With the next general elections due in 2019, Mr Modi will be tempted to deliver one more big bang to dazzle voters. Watch out for dramatic action against wealthy individuals holding properties in others’ names to hide their ownership.

Graphical abstract: Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Open Access Paper

Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses

We will make continued progress in building a Healthy China.
事实证明,许多投资者站在了库克这一边。经历了动荡的2013年,苹果股价在这次股东大会后上涨了约50%,一度将苹果市值推至7000亿美元之上。

Graphical abstract: Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
Open Access Paper

The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor

I'm only a child yet I know we are all in this together and should act as one single world towards one single goal. 我身为小孩都知道,我们在地球的母亲怀中都是孩子。我们应该为了相同的目的进行相同的行动!
欧盟完成与墨西哥现有贸易协议的(重新)谈判也是如此。在与墨西哥签订协议上,布鲁塞尔很可能比特朗普先冲过终点线。
泰勒·斯威夫特《名誉》

Graphical abstract: The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
From the themed collection: 新华社:稳健运行 底气更足
Open Access Paper

Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study

So many are tuning out. Denial. Truth is, bubbles are everywhere. Ready to blow. The evidence is accelerating, with only one obvious conclusion: Max 98% risk at a flashpoint. This 2014 crash is virtually guaranteed. There's but a narrow 2% chance of dodging this bullet.
We will speed up the reform of SOEs and state capital.
在这部1998年的古装剑侠动作电影中,安东尼奥·班德拉斯扮演了一个无聊的贵族,他有时会扮成蒙面歹徒,从腐败领导人手中拯救加州的墨西哥平民。虽然佐罗听起来可能像个普通的老派超级英雄,但是《佐罗的面具》依据的故事大部分来源于现实世界中,一个叫乔伊·穆里埃塔的亡命之徒。

Graphical abstract: Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Open Access Paper

Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework

This can involve everything from not responding to e-mails to not being aware of how you come across in an e-mail. If you have a bad habit of taking too long to check or respond to e-mails, you could miss important meetings or deadlines, cause delays or confusion, or come off as unprofessional.
Jackdaw Research的简?道森(Jan Dawson)表示,最近几个月“他表现得更加意气风发和充满自信”。

Graphical abstract: Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Open Access Paper

Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach

Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.

Graphical abstract: Several coumarin derivatives and their Pd(ii) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Open Access Paper

Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors

Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.

Graphical abstract: Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Open Access Paper

Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins

Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.

Graphical abstract: Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Open Access Paper

Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform

There will not likely be a return to the whiteness of social dominance and exclusive national identity. Immigration cannot be halted without damaging Western nations’ economies; immigrants who have already arrived cannot be expelled en masse without causing social and moral damage. And the other groups who seem to be “cutting in line” are in fact getting a chance at progress that was long denied them.
The so-called IP-BOX will work on iPhones running iOS 7 and older. It takes 6 seconds to 17 hours hours to crack the four-digit passcode. The Daily Mail purchased the device and cracked the code on an Apple iPhone 5c in 6 hours. A version that will work on iPhones running iOS 9 will be available later this month.
9.消防员

Graphical abstract: Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Open Access Paper

A modular microarray imaging system for highly specific COVID-19 antibody testing

The U.S. is set to add nearly 3 million jobs in 2014 — the biggest increase since 1999. The burst in job creation, expected to continue in 2015, is sure to fuel consumer spending. So, too, will a plunge in gasoline prices that's given households extra cash to spare on other goods and services. See: Americans saved $14 billion as gasoline prices declined in 2014.
2.SpaceX demonstrates a big step towards fully reusable space craft

Graphical abstract: A modular microarray imaging system for highly specific COVID-19 antibody testing
Open Access Paper

Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms

源于:last(adj 最后的)
像中国人口这么多的国家,关于寂寞的病毒式模仿会这么流行实在是件很讽刺的事情。这句看上去很无厘头的话被用在了所有可能搭配的排列中,用在了所有场合,比如,“哥看的不是书,是寂寞。”
6. You dressed 10 times nicer than usual yesterday。

Graphical abstract: Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
From the themed collection: 易到再寻买家 恒大否认将接手
Open Access Paper

Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening

The cemetery was found in the city of Kucha, which is located in present-day northwest China. Ten tombs were excavated, seven of which turned out to be large brick structures.

Graphical abstract: Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Open Access Paper

Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations

A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.

Graphical abstract: Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
Open Access Paper

Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets

两次发生在洛杉矶的反抗时间之旅。两次对女人之间时而棘手的团结的赞颂。四位演员的精彩表演,来自吉塔娜·基基·罗德里格斯(Kitana Kiki Rodriguez)、米娅·泰勒(Mya Taylor)、茱莉亚·加纳,以及了不起的莉莉·汤姆林。《与外婆同行》是制片公司资深导演的作品,《橘色》是用iPhone手机拍摄。任何哀悼电影已死的人,都应该闭上嘴巴,看看这两部影片。
指数:96.6

Graphical abstract: Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
Open Access Paper

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

如果法国总统奥朗德在2012年上任后没有主动减薪30%,他的排名还能更靠前。
Perhaps my favorite profile this year was Kiki Zhao’s stirring depiction of the remarkable Yu Xiuhua, now one of China’s most read poets, a woman with cerebral palsy who lived most of her 41 years on a farm, writing at a low table. She never finished high school, and says she “could write before she could read.” Now, she is invited to places like Stanford University and fends off comparisons to Emily Dickinson.

Graphical abstract: A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
Open Access Paper

An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19

3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.

Graphical abstract: An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
Open Access Paper

Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies

“We have resolved this matter and will move forward to build on the important actions Honda has already taken to address our past shortcomings in early warning reporting,” said RickSchostek, Honda executive vice president, in a statement. “We continue to fully cooperate with NHTSA to achieve greater transparency and to further enhance our reporting practices.”
7. Smart cookie oven

Graphical abstract: Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
From the themed collection: 北京4家楼盘标价不规范被罚1000元
Paper

Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material

上周二,Snapchat推出了一种名为Discover的服务,Vice、CNN和《人物》杂志等媒体可通过它在Snapchat发布视频内容。已经有几个频道推出广告服务,要价可不便宜。据《广告周刊》报道,Snapchat的广告标价是每天75万美元。
1. “暂时没有名字的泡沫”引发30年来的最大规模崩盘

Graphical abstract: Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
Open Access Paper

A facile assay for rapid detection of COVID-19 antibodies

Sweden, one of the most generous countries in terms of contributing funds to humanitarian aid, ranks No. 6 overall. The country is No. 2 in Citizenship and No. 1 in Best Countries for Green Living.

Graphical abstract: A facile assay for rapid detection of COVID-19 antibodies
Open Access Paper

Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses

“This growth is further backed by Video Editing making an appearance at number 3 on the list with a 19% increase,” the report states, “as video content becomes one of the initial draws and call to actions for most customer-focused websites. Heavy video marketing through social media also increases this demand.”
《极盗车神》
adj. 一致的,始终如一的
9、另一地球

Graphical abstract: Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Open Access Paper

Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2

持有40亿美元亚洲相关资产的美国投资机构Cohen & Steers的基金经理梁纬濂(William Leung)认同这一点。他主张,随着价格下跌,投机性投资将被驱逐出市场。他补充称,行业中另类投资热度上升的趋势应当意味着,即便基础资产的价值上涨得更慢,房地产投资信托的价格也会上升。“我们认为,这次调整的幅度将不会太大,”他说。

Graphical abstract: Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Open Access Paper

Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease

设计师布莱恩-卡朋特和布兰德-霍克因为酷爱户外运动而受到启发,决定想出一种创意方式,能够随处搭吊床。
Currency movements have had a strong impact on agricultural commodity prices this year, with the UK’s referendum on the EU leading to a sharp fall in the pound that pushed up the price of food imports and boosted agricultural exports.
7.洗牙师

Graphical abstract: Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
Open Access Paper

Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19

Prices at China's factory gates fell for a 34th consecutive month in December, pushed down by falling energy and commodity prices.
据国家统计局上周三发布的调查显示,去年,我国人口总数有所增长,且男女性别比例及国民受教育程度均有所改善。

Graphical abstract: Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Paper

Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties

“He’s informal, candid and approachable,” says Ginni Rometty, chief executive of IBM, who praises him as “very authentic. It’s the hallmark of a modern CEO. What you see is what you get.”
The main culprit for the deceleration was food, though food inflation is higher than the overall index. Food prices were up 1.9 per cent in October, down from 2.7 per cent in September and 3.7 per cent in August. Non-food inflation ticked down 0.9 per cent from 1.0 per cent.

Graphical abstract: Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
Open Access Paper

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease

Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.

Graphical abstract: Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Paper

Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

The Great American Eclipse

Graphical abstract: Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Open Access Paper

Anti-HIV drug repurposing against SARS-CoV-2

这只漂亮的伯曼猫在Ins上有超过128000名粉丝,而且它还是拉格菲尔德众多设计的灵感。
德马库斯-考辛斯、塞尔吉-伊巴卡和路易斯-威廉姆斯的交易早在截止时间——美国东部时间周四下午3点之前就已经完成了,在余下完成压哨交易的角色球员里,只有像泰-吉布森和PJ-塔克算是相对大牌的球员了。
1.Asana

Graphical abstract: Anti-HIV drug repurposing against SARS-CoV-2
Paper

Length-scale dependence of protein hydration-shell density

中国疾病预防控制中心主任韩孟杰表示:“有过性经历的大学生安全套的使用率还不到40%。”
推动社会治理创新。
China's best performances by subject this year come from Tsinghua University, with three top-10 places, and Peking University, with two top-10 places. Tsinghua University finishes eighth in both Architecture/Built Environment and in Engineering (Civil and Structural). Tsinghua comes in 10th place in the world's Materials Science subject rankings.
《好时光》

Graphical abstract: Length-scale dependence of protein hydration-shell density
Open Access Paper

High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus

May the bright and festive glow of New Year candle warm the days all the year through. Hoping you will have a wonderful time enjoying New Year that is happy in every way.愿明亮喜庆的新年烛光温暖一年中的每个日日夜夜,祝你欢欢喜喜度新年!
单词turkey 联想记忆:

Graphical abstract: High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Paper

A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor

大学的发言人告诉记者:如果Siddeeq先生在之后的53年还是收不到这封信,他肯定会抱怨我们的效率。
该项目在毕业3年后的职业晋升方面排名第二。Tiemba项目的毕业生数量迄今只有约250人,使他们成为一个精英团体。
最佳竞技真人秀:《美国之声》(The Voice , NBC)

Graphical abstract: A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
From the themed collection: 北京地下室住户两天搬进新家
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报告称,北上广深等一线城市居民承受着较大的经济压力;而四线及以下城市的工作机会较少,人脉在生活的各个方面都起着重要作用。
Microscopic as the subjects are, the benefits of the scientists’ research are set to be huge.

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